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Acyl-coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10485 inhibits human ACAT-1 and ACAT-2 with an IC50 values of 95 and 81 μM, respectively. It also inhibits copper-mediated oxidation of low density lipoproteins by 91% at a concentration of 2 μM.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $88 | 35 days | |
10 mg | $165 | 35 days | |
50 mg | $685 | 35 days | |
100 mg | $1,190 | 35 days |
Description | Acyl-coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10485 inhibits human ACAT-1 and ACAT-2 with an IC50 values of 95 and 81 μM, respectively. It also inhibits copper-mediated oxidation of low density lipoproteins by 91% at a concentration of 2 μM. |
Molecular Weight | 477.51 |
Formula | C27H27NO7 |
Cas No. | 615264-62-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMF: 20 mg/mL (41.88 mM), Sonication is recommended. Ethanol:PBS (pH 7.2)(1:3): 0.25 mg/mL (0.52 mM), Sonication is recommended. DMSO: 20 mg/mL (41.88 mM), Sonication is recommended. Ethanol: 20 mg/mL (41.88 mM), Sonication is recommended. |
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