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CAY10722

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Catalog No. T35822Cas No. 388086-13-3

CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM). SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type. High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load. In contrast, low SIRT3 expression in patient-derived breast cancer cells is correlated with shorter survival.

CAY10722

CAY10722

😃Good
Catalog No. T35822Cas No. 388086-13-3
CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM). SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type. High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load. In contrast, low SIRT3 expression in patient-derived breast cancer cells is correlated with shorter survival.
Pack SizePriceAvailabilityQuantity
5 mg$348 35 days
10 mg$595 35 days
25 mg$1,330 35 days
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Product Introduction

Bioactivity
Description
CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM). SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type. High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load. In contrast, low SIRT3 expression in patient-derived breast cancer cells is correlated with shorter survival.
Chemical Properties
Molecular Weight397.25
FormulaC21H14Cl2N2O2
Cas No.388086-13-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 10 mg/mL (25.17 mM), Sonication is recommended.
Ethanol: Slightly soluble
DMF: 10 mg/mL (25.17 mM), Sonication is recommended.
DMSO:PBS(pH7.2) (1:1): 0.5 mg/mL (1.26 mM), Sonication is recommended.
Solution Preparation Table
DMSO:PBS(pH7.2) (1:1)/DMSO/DMF
1mg5mg10mg50mg
1 mM2.5173 mL12.5865 mL25.1731 mL125.8653 mL
DMSO/DMF
1mg5mg10mg50mg
5 mM0.5035 mL2.5173 mL5.0346 mL25.1731 mL
10 mM0.2517 mL1.2587 mL2.5173 mL12.5865 mL
20 mM0.1259 mL0.6293 mL1.2587 mL6.2933 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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