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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $193 | 35 days | |
5 mg | $718 | 35 days | |
10 mg | $1,340 | 35 days |
Description | Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-2 is a nutlin-3 analog in which trifluoromethyl groups have been substituted for chlorine on the 2 phenyl rings. At high concentrations, caylin-2 inhibits the growth of HCT116 cells with an IC50 of approximately 8 μM, making it about 10-fold less potent than nutlin-3. Interestingly, at concentrations between 5-100 nM, caylin-2 promotes the growth of HCT116 cells approximately 40% compared to untreated cells. The mechanism of the growth promoting properties of caylin-2 have not yet been elucidated. |
Molecular Weight | 648.6 |
Formula | C32H30F6N4O4 |
Cas No. | 1392830-09-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMSO: Soluble |
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