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CB7993113
CB7993113 is a potent AHR antagonist with an IC50 of 0.33 μM, directly binding the AHR protein and blocking its nuclear translocation. It inhibits polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90%, respectively [1].
Catalog No. T86013Cas No. 819827-50-4
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CB7993113
Catalog No. T86013Cas No. 819827-50-4
CB7993113 is a potent AHR antagonist with an IC50 of 0.33 μM, directly binding the AHR protein and blocking its nuclear translocation. It inhibits polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90%, respectively [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Bioactivity
Chemical Properties
| Description | CB7993113 is a potent AHR antagonist with an IC50 of 0.33 μM, directly binding the AHR protein and blocking its nuclear translocation. It inhibits polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90%, respectively [1]. |
| In vitro | CB7993113 exhibits no toxicity when added at concentrations of at least 20 μM to various human cells, including HepG2 liver cancer cells, BP1, D3, Hs578T, or MDA-MB-231 breast cancer cells, as well as primary human induced pluripotent stem cells [1]. Additionally, CB7993113 significantly reduces the in vitro invasive phenotype of ER-/PR-/HER2- breast cancer cells [1]. |
| In vivo | CB7993113 is effective in blocking the acute hepatic CYP1A1 induction and in vivo bone marrow toxicity induced by 50 mg/kg DMBA [1]. |
| Molecular Weight | 364.15 |
| Formula | C15H10BrNO5 |
| Cas No. | 819827-50-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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