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CDK-IN-6

Name: CDK-IN-6
Brand: TargetMol
SKU: T36741
Rating: 4.5 (1 reviews)

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Catalog No. T36741Cas No. 779353-02-5

CDK-IN-6, a pyrazolo[1,5-a]pyrimidine compound, exhibits potent anticancer activities as a CDK inhibitor[1].

CDK-IN-6

🥰Excellent

Catalog No. T36741Cas No. 779353-02-5

CDK-IN-6, a pyrazolo[1,5-a]pyrimidine compound, exhibits potent anticancer activities as a CDK inhibitor[1].

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Product Introduction

Bioactivity

Description	CDK-IN-6, a pyrazolo[1,5-a]pyrimidine compound, exhibits potent anticancer activities as a CDK inhibitor[1].
In vitro	CDKs, including CDK1, CDK2, CDK3, CDK4, CDK5, CDK6, CDK7, CDK8, among others, play specific roles in the progression of the cell cycle, being categorized into G1, S, or G2M phase enzymes. The unchecked proliferation characteristic of cancer cells often involves the frequent misregulation of CDK function in various significant solid tumors[1].

Chemical Properties

Molecular Weight	380.49
Formula	C₂₁H₂₈N₆O
Cas No.	779353-02-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (131.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6282 mL	13.1409 mL	26.2819 mL	131.4095 mL
5 mM	0.5256 mL	2.6282 mL	5.2564 mL	26.2819 mL
10 mM	0.2628 mL	1.3141 mL	2.6282 mL	13.1409 mL
20 mM	0.1314 mL	0.6570 mL	1.3141 mL	6.5705 mL
50 mM	0.0526 mL	0.2628 mL	0.5256 mL	2.6282 mL
100 mM	0.0263 mL	0.1314 mL	0.2628 mL	1.3141 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

CDK-IN-6CDK IN 6CDKIN6