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cGAMP

Name: cGAMP
Brand: TargetMol
SKU: T13606
Rating: 4.5 (1 reviews)

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Catalog No. T13606Cas No. 849214-04-6

Alias Cyclic GMP-AMP, 3',3'-cGAMP

cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It also is a STING ligand.

cGAMP

😃Good

Catalog No. T13606Alias Cyclic GMP-AMP, 3',3'-cGAMPCas No. 849214-04-6

cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It also is a STING ligand.

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25 mg	$1,520	Backorder

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Product Introduction

Bioactivity

Description	cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It also is a STING ligand.
In vitro	cGAMP directly activates murine and human dendritic cells in vitro. cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice [2]. On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding IL-1, IL-6, or TNF [3]. cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs [4].
In vivo	cGAMP stimulates the antigen-specific cytokine production by spleen cells of immunized mice [2].
Alias	Cyclic GMP-AMP, 3',3'-cGAMP

Chemical Properties

Molecular Weight	674.41
Formula	C₂₀H₂₄N₁₀O₁₃P₂
Cas No.	849214-04-6
Relative Density.	2.61 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 20 mg/mL (29.66 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.4828 mL	7.4139 mL	14.8278 mL	74.1389 mL
5 mM	0.2966 mL	1.4828 mL	2.9656 mL	14.8278 mL
10 mM	0.1483 mL	0.7414 mL	1.4828 mL	7.4139 mL
20 mM	0.0741 mL	0.3707 mL	0.7414 mL	3.7069 mL

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Keywords

Endogenous MetabolitecGAMP