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CGP-53153
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Catalog No. T10780Cas No. 149281-19-6
CGP-53153 is a steroidal inhibitor of 5 alpha-reductase, with IC50 values of 36 nM in rat prostatic tissue and 262 nM in human prostatic tissue.
CGP-53153
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Catalog No. T10780Cas No. 149281-19-6
CGP-53153 is a steroidal inhibitor of 5 alpha-reductase, with IC50 values of 36 nM in rat prostatic tissue and 262 nM in human prostatic tissue.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | CGP-53153 is a steroidal inhibitor of 5 alpha-reductase, with IC50 values of 36 nM in rat prostatic tissue and 262 nM in human prostatic tissue. |
| Targets&IC50 | 5α reductase (rat):36 nM , 5α reductase (human):262 nM |
| In vitro | CGP-53153 competitively inhibits rat microsomal 5 alpha-reductase from the prostate, with an IC50 of 36 nM, compared to the reference compound finasteride (IC50: 11 nM). |
| In vivo | CGP-53153, administered orally at a dose of 0.01 mg/kg, significantly reduces T-propionate-induced prostate growth. Further, it notably lowers prostate weight by 31% and 37% at doses of 3 and 10 mg/kg, respectively. A 12-week treatment regimen with CGP-53153 diminishes prostate volume by over 70% in individual dogs without affecting body weight or the weight of any tested organ. |
| Molecular Weight | 383.53 |
| Formula | C23H33N3O2 |
| Cas No. | 149281-19-6 |
| Relative Density. | 1.118 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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