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Cimetidine sulfoxide

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Cimetidine sulfoxide

Catalog No. T38058Cas No. 54237-72-8

Cimetidine sulfoxide (Cimetidine sulphoxide), a metabolite of Cimetidine, is a histamine H2-receptor antagonist with potential applications in treating peptic ulcer disease and upper gastrointestinal hemorrhage [1].

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Product Introduction

Bioactivity

Description	Cimetidine sulfoxide (Cimetidine sulphoxide), a metabolite of Cimetidine, is a histamine H2-receptor antagonist with potential applications in treating peptic ulcer disease and upper gastrointestinal hemorrhage [1].
In vitro	Active transport of Cimetidine across the rat small intestine occurs at lower substrate concentrations (40 and 200 μM) but becomes obscured by passive transfer at higher concentrations (400 μM). Following specific incubations, Cimetidine sulfoxide is present[2].
In vivo	The enantiomeric composition of Cimetidine sulfoxide in male Wistar rats' urine (24 h) was analyzed following a 30 mg/kg oral dose of Cimetidine (po), resulting in an enantiomeric ratio of (+/-) 57:43[3].

Chemical Properties

Molecular Weight	268.34
Formula	C10H16N6OS
Cas No.	54237-72-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 83.33 mg/mL (310.54 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7266 mL	18.6331 mL	37.2662 mL	186.3308 mL
5 mM	0.7453 mL	3.7266 mL	7.4532 mL	37.2662 mL
10 mM	0.3727 mL	1.8633 mL	3.7266 mL	18.6331 mL
20 mM	0.1863 mL	0.9317 mL	1.8633 mL	9.3165 mL
50 mM	0.0745 mL	0.3727 mL	0.7453 mL	3.7266 mL
100 mM	0.0373 mL	0.1863 mL	0.3727 mL	1.8633 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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Keywords

Cimetidine sulfoxide