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Description | Cimetidine sulfoxide (Cimetidine sulphoxide), a metabolite of Cimetidine, is a histamine H2-receptor antagonist with potential applications in treating peptic ulcer disease and upper gastrointestinal hemorrhage [1]. |
In vitro | Active transport of Cimetidine across the rat small intestine occurs at lower substrate concentrations (40 and 200 μM) but becomes obscured by passive transfer at higher concentrations (400 μM). Following specific incubations, Cimetidine sulfoxide is present[2]. |
In vivo | The enantiomeric composition of Cimetidine sulfoxide in male Wistar rats' urine (24 h) was analyzed following a 30 mg/kg oral dose of Cimetidine (po), resulting in an enantiomeric ratio of (+/-) 57:43[3]. |
Molecular Weight | 268.34 |
Formula | C10H16N6OS |
Cas No. | 54237-72-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 83.33 mg/mL (310.54 mM), Sonication and heating to 60℃ are recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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