Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Clozapine dihydrochloride

😃Good
Catalog No. T203225Cas No. 2711603-38-0
Alias HF 1854 dihydrochloride

Clozapine (HF 1854) dihydrochloride is utilized for researching psychiatric disorders. This compound exhibits high affinity for numerous neuroreceptors and acts as an effective antagonist of dopamine receptors, with a Ki value of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor, with Ki values of 9.5 nM and 4 nM, respectively. Additionally, Clozapine is a selective agonist of the muscarinic M4 receptor (EC50 = 11 nM).

Clozapine dihydrochloride

Clozapine dihydrochloride

😃Good
Catalog No. T203225Alias HF 1854 dihydrochlorideCas No. 2711603-38-0
Clozapine (HF 1854) dihydrochloride is utilized for researching psychiatric disorders. This compound exhibits high affinity for numerous neuroreceptors and acts as an effective antagonist of dopamine receptors, with a Ki value of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor, with Ki values of 9.5 nM and 4 nM, respectively. Additionally, Clozapine is a selective agonist of the muscarinic M4 receptor (EC50 = 11 nM).
Pack SizePriceAvailabilityQuantity
10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
Bulk & Custom
Add to Cart
Questions
View More
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
Clozapine (HF 1854) dihydrochloride is utilized for researching psychiatric disorders. This compound exhibits high affinity for numerous neuroreceptors and acts as an effective antagonist of dopamine receptors, with a Ki value of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor, with Ki values of 9.5 nM and 4 nM, respectively. Additionally, Clozapine is a selective agonist of the muscarinic M4 receptor (EC50 = 11 nM).
Targets&IC50
mAChR1:9.5 nM (Ki), α2-adrenergic receptor:51 nM (Ki), mAChR4:11 nM (EC50), 5-HT2A receptor:4 nM (Ki), D2 Receptor:75 nM (Ki)
In vitro
Clozapine (HF 1854) is a D2 receptor antagonist with a K\(_i\) of 75 nM, and it also blocks serotonin 5HT2A receptors with a K\(_i\) of 4 nM, inhibits muscarinic M1 receptors with a K\(_i\) of 9.5 nM, and blocks α2-adrenergic receptors with a K\(_i\) of 51 nM. At concentrations of 0-1 μM for 24 hours, Clozapine modulates receptor levels in HeLa cells by downregulating 5-HT 6 and upregulating 5-HT 7 receptors. It acts as a full agonist of muscarinic M4 receptors expressed in CHO cells, with an EC\(_{50}\) of 11 nM.
In vivo
Clozapine (HF 1854) administered at 25 mg/kg/day via intraperitoneal injection for 21 days exhibits antipsychotic effects in a mouse model of psychosis induced by lysergic acid diethylamide.
AliasHF 1854 dihydrochloride
Chemical Properties
Molecular Weight399.75
FormulaC18H21Cl3N4
Cas No.2711603-38-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: buy Clozapine dihydrochloride | purchase Clozapine dihydrochloride | Clozapine dihydrochloride cost | order Clozapine dihydrochloride | Clozapine dihydrochloride chemical structure | Clozapine dihydrochloride in vivo | Clozapine dihydrochloride in vitro | Clozapine dihydrochloride formula | Clozapine dihydrochloride molecular weight