Shopping Cart

Remove All
Your shopping cart is currently empty

CMK

Name: CMK
Brand: TargetMol
SKU: T10845
Price: 30 EUR
Availability: InStock
Rating: 4.5 (1 reviews)

🥰Excellent

Catalog No. T10845Cas No. 821794-90-5

CMK, an RSK2 kinase inhibitor, shows similar potency but less chemical stability compared with FMK.

CMK

🥰Excellent

Catalog No. T10845Cas No. 821794-90-5

CMK, an RSK2 kinase inhibitor, shows similar potency but less chemical stability compared with FMK.

Product information is being updated, if you want to purchase, please click the bulk custom button.

Bulk & Custom

Questions

Resource Download

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

Product Introduction

Bioactivity

Description	CMK, an RSK2 kinase inhibitor, shows similar potency but less chemical stability compared with FMK.
In vitro	CMK inhibits the growth of Cdc5 (L158G) with an IC50 of 36 nM, significantly more effective than its action on wild type Cdc5 (>30 μM). It causes a concentration-dependent first cell cycle mitotic arrest in the cdc5-as1 strain (IC50: 1.1 μM) and leads to anaphase arrest and delay in anaphase spindle migration.

Chemical Properties

Molecular Weight	358.82
Formula	C₁₈H₁₉ClN₄O₂
Cas No.	821794-90-5
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 150 mg/mL (418.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7869 mL	13.9346 mL	27.8691 mL	139.3456 mL
5 mM	0.5574 mL	2.7869 mL	5.5738 mL	27.8691 mL
10 mM	0.2787 mL	1.3935 mL	2.7869 mL	13.9346 mL
20 mM	0.1393 mL	0.6967 mL	1.3935 mL	6.9673 mL
50 mM	0.0557 mL	0.2787 mL	0.5574 mL	2.7869 mL
100 mM	0.0279 mL	0.1393 mL	0.2787 mL	1.3935 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

CMK