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COX-2/NO-IN-1

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Catalog No. T60403

COX-2/NO-IN-1 is an orally active nitric oxide synthase (iNOS) and NO (IC50 of 3.52 μM) inhibitor that also suppresses COX-2 expression, exhibiting anti-inflammatory effects and reducing pathological damage to kidney tissues [1].

COX-2/NO-IN-1

COX-2/NO-IN-1

😃Good
Catalog No. T60403
COX-2/NO-IN-1 is an orally active nitric oxide synthase (iNOS) and NO (IC50 of 3.52 μM) inhibitor that also suppresses COX-2 expression, exhibiting anti-inflammatory effects and reducing pathological damage to kidney tissues [1].
Pack SizePriceAvailabilityQuantity
25 mg$1,52010-14 weeks
50 mg$1,98010-14 weeks
100 mg$2,50010-14 weeks
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Product Introduction

Bioactivity
Description
COX-2/NO-IN-1 is an orally active nitric oxide synthase (iNOS) and NO (IC50 of 3.52 μM) inhibitor that also suppresses COX-2 expression, exhibiting anti-inflammatory effects and reducing pathological damage to kidney tissues [1].
In vitro
COX-2/NO-IN-1 (Compound 13b; 2.5-10 μM) exhibits notable anti-inflammatory effects by inhibiting nitric oxide (NO, IC50 = 3.52 μM), TNF-α, and IL-6 production (84.1% and 33.6%, respectively) in a dose-dependent manner, and reducing the expression of iNOS, COX-2, and TLR4 proteins in LPS-stimulated RAW264.7 cells [1].
In vivo
In C57BL/6 mice with cisplatin-induced AKI, COX-2/NO-IN-1 (Compound 13b; 15–30 mg/kg; p.o.) effectively maintains normal metabolic function, inhibits inflammation, and mitigates kidney tissue pathological damage.
Chemical Properties
Molecular Weight257.28
FormulaC15H15NO3
Storage & Solubility Information
StorageShipping with blue ice.

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