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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 10-14 weeks | |
50 mg | $1,980 | 10-14 weeks | |
100 mg | $2,500 | 10-14 weeks |
Description | COX-2/NO-IN-1 is an orally active nitric oxide synthase (iNOS) and NO ( IC 50 of 3.52 μM) inhibitor as well as suppresses the expression of COX-2. COX-2/NO-IN-1 has anti-inflammatory effects and reduces pathological damage to kidney tissues[1]. |
In vitro | COX-2/NO-IN-1 (Compound 13b; 2.5-10 μM) exhibits notable anti-inflammatory effects by inhibiting nitric oxide (NO, IC 50 = 3.52 μM), TNF-α, and IL-6 production (84.1% and 33.6%, respectively) in a dose-dependent manner, and by reducing the expression of iNOS, COX-2, and TLR4 proteins in LPS-stimulated RAW264.7 cells [1]. |
In vivo | In C57BL/6 mice with cisplatin-induced AKI, COX-2/NO-IN-1 (Compound 13b; 15-30 mg/kg; p.o.) effectively maintains normal metabolic function, inhibits inflammatory development, and improves the pathological damage of kidney tissue in AKI mice. |
Molecular Weight | 257.28 |
Formula | C15H15NO3 |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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