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COX-1-IN-1
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Catalog No. T86080Cas No. 1369503-03-6
COX-1-IN-1 (compound 15a) selectively inhibits cyclooxygenase (COX), exhibiting an IC50 of 0.23 μM for COX-1 and greater than 50 μM for COX-2, resulting in a selectivity index (COX-2 IC50/COX-1 IC50) of 217. Additionally, COX-1-IN-1 effectively inhibits platelet aggregation [1].
COX-1-IN-1
😃Good
Catalog No. T86080Cas No. 1369503-03-6
COX-1-IN-1 (compound 15a) selectively inhibits cyclooxygenase (COX), exhibiting an IC50 of 0.23 μM for COX-1 and greater than 50 μM for COX-2, resulting in a selectivity index (COX-2 IC50/COX-1 IC50) of 217. Additionally, COX-1-IN-1 effectively inhibits platelet aggregation [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | COX-1-IN-1 (compound 15a) selectively inhibits cyclooxygenase (COX), exhibiting an IC50 of 0.23 μM for COX-1 and greater than 50 μM for COX-2, resulting in a selectivity index (COX-2 IC50/COX-1 IC50) of 217. Additionally, COX-1-IN-1 effectively inhibits platelet aggregation [1]. |
| Targets&IC50 | COX-2:50 μM, COX-1:0.23 μM |
| In vitro | COX-1-IN-1 inhibits arachidonic acid (AA)-induced platelet aggregation with an IC50 value of 1 μM and exhibits low cytotoxicity toward cells and platelets at 100 μM over a 3-hour incubation period [1]. Cell Cytotoxicity Assay: Cell Line: Vero; Concentration: 100 μM; Incubation Time: 3 h; Result: Demonstrated platelet and cell viabilities above 90%. |
| Molecular Weight | 323.39 |
| Formula | C20H21NO3 |
| Cas No. | 1369503-03-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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