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CYT296

Name: CYT296
Brand: TargetMol
SKU: T78520
Rating: 4.5 (1 reviews)

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Catalog No. T78520Cas No. 1799392-31-6

CYT296 is a chromatin de-condensation agent that enhances the efficiency of induced pluripotent stem cell (iPSC) generation mediated by defined factors (OSKM) and promotes an open chromatin state in Mouse Embryonic Fibroblast (MEFs), aiding in somatic cell reprogramming. This compound has potential applications in cell replacement therapies and drug screening research [1].

CYT296

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Catalog No. T78520Cas No. 1799392-31-6

Pack Size	Price	Availability	Quantity
5 mg	Inquiry	8-10 weeks
50 mg	Inquiry	8-10 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	CYT296 is a chromatin de-condensation agent that enhances the efficiency of induced pluripotent stem cell (iPSC) generation mediated by defined factors (OSKM) and promotes an open chromatin state in Mouse Embryonic Fibroblast (MEFs), aiding in somatic cell reprogramming. This compound has potential applications in cell replacement therapies and drug screening research [1].
In vitro	CYT296 (250nM, 72 hours) alters the chromatin architecture in MEFs to facilitate Yamanaka factor accessibility and enhance the reprogramming process [1]. Additionally, CYT296 (250nM, 72 hours) as a small-molecule inhibitor disrupts heterochromatin assembly in MEFs, significantly improving the generation of iPSCs [1].
In vivo	CYT296, administered subcutaneously in a single dose (皮下注射, 一次), effectively induced pluripotency [1] in iPSCs derived from NOD-SCID mice, with tests conducted on 10-15 4F- and 2F-iPSC clones.

Chemical Properties

Molecular Weight	296.38
Formula	C₁₈H₁₆O₂S
Cas No.	1799392-31-6

Storage & Solubility Information

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Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc