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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,670 | 1-2 weeks | |
50 mg | $2,180 | 1-2 weeks | |
100 mg | $2,800 | 1-2 weeks |
Description | DBPR112 is a potent EGFR inhibitor (IC50=487 nM) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer. DBPR112), DBPR112 not only displayed a potent inhibitory activity against EGFRL858R/T790M double mutations but also exhibited tenfold potency better than the third-generation inhibitor, osimertinib,against EGFR and HER2 exon 20 insertion mutations. Overall, pharmacokinetic improvement through lead-to-candidate optimization yielded fourfold oral AUC better that afatinib along with F = 41.5%, an encouraging safety profile, and significant antitumor efficacy in in vivo xenograft models. |
Molecular Weight | 570.09 |
Formula | C32H32ClN5O3 |
Cas No. | 2889316-21-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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