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DNA Gyrase-IN-11

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Catalog No. T88598Cas No. 2497486-58-3

DNA Gyrase-IN-11 (Compound 23Be) is an inhibitor of protein synthesis (IC50 of 0.74 μM) and DNA replication. It specifically targets and inhibits DNA Gyrase (DNA Gyrase), which suppresses the supercoiling of DNA in E. coli with an IC50 of 11.9 μM. Moreover, DNA Gyrase-IN-11 exhibits antibacterial activity against Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Staphylococcus aureus, with minimum inhibitory concentrations (MIC) ranging from 0.008 to 0.25 μg/mL.

DNA Gyrase-IN-11

DNA Gyrase-IN-11

😃Good
Catalog No. T88598Cas No. 2497486-58-3
DNA Gyrase-IN-11 (Compound 23Be) is an inhibitor of protein synthesis (IC50 of 0.74 μM) and DNA replication. It specifically targets and inhibits DNA Gyrase (DNA Gyrase), which suppresses the supercoiling of DNA in E. coli with an IC50 of 11.9 μM. Moreover, DNA Gyrase-IN-11 exhibits antibacterial activity against Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Staphylococcus aureus, with minimum inhibitory concentrations (MIC) ranging from 0.008 to 0.25 μg/mL.
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Product Introduction

Bioactivity
Description
DNA Gyrase-IN-11 (Compound 23Be) is an inhibitor of protein synthesis (IC50 of 0.74 μM) and DNA replication. It specifically targets and inhibits DNA Gyrase (DNA Gyrase), which suppresses the supercoiling of DNA in E. coli with an IC50 of 11.9 μM. Moreover, DNA Gyrase-IN-11 exhibits antibacterial activity against Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Staphylococcus aureus, with minimum inhibitory concentrations (MIC) ranging from 0.008 to 0.25 μg/mL.
Chemical Properties
Molecular Weight1190.36
FormulaC61H84FN7O16
Cas No.2497486-58-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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