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DPP-8/9 probe-1

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Catalog No. T86304Cas No. 3020859-80-4

DPP-8/9 probe-1 (compound 20) is a fluorescent probe designed to specifically target and label Dipeptidyl Peptidase DPP8/9, allowing for its visualization through fluorescence microscopy in vitro when active. This compound incorporates a nitrobenzoxadiazole (NBD) tag, demonstrating a high affinity and selectivity for DPP8/9, with significant preference over other S9 family enzymes, evidenced by IC 50 values of 210 nM and 15 nM, respectively. [9] [1]

DPP-8/9 probe-1

DPP-8/9 probe-1

😃Good
Catalog No. T86304Cas No. 3020859-80-4
DPP-8/9 probe-1 (compound 20) is a fluorescent probe designed to specifically target and label Dipeptidyl Peptidase DPP8/9, allowing for its visualization through fluorescence microscopy in vitro when active. This compound incorporates a nitrobenzoxadiazole (NBD) tag, demonstrating a high affinity and selectivity for DPP8/9, with significant preference over other S9 family enzymes, evidenced by IC 50 values of 210 nM and 15 nM, respectively. [9] [1]
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Product Introduction

Bioactivity
Description
DPP-8/9 probe-1 (compound 20) is a fluorescent probe designed to specifically target and label Dipeptidyl Peptidase DPP8/9, allowing for its visualization through fluorescence microscopy in vitro when active. This compound incorporates a nitrobenzoxadiazole (NBD) tag, demonstrating a high affinity and selectivity for DPP8/9, with significant preference over other S9 family enzymes, evidenced by IC 50 values of 210 nM and 15 nM, respectively. [9] [1]
Targets&IC50
DPP-4:44 μM, DPP-8:210 nM, DPP-9:15 nM
In vitro
DPP-8/9 probe-1 (compound 20) (10 μM; 30 min) effectively stains and visualizes DPP-8/9 in THP-1 monocyte cells [1]. Using immunofluorescence [1], the experiment indicates that lower concentrations (0.5 μM, 1 μM, and 2 μM) are insufficient for adequate in-cell staining. Optimal results are achieved at a concentration of 10 μM, where visualization is markedly improved.
Chemical Properties
Molecular Weight637.66
FormulaC31H36FN7O7
Cas No.3020859-80-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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