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EGFR/HER2-IN-14

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Catalog No. T88221Cas No. 3034701-54-4

EGFR/HER2-IN-14 (Compd 46) serves as an inhibitor for drug-resistant mutant EGFR/HER2s. This compound is utilized in cancer research.

EGFR/HER2-IN-14

EGFR/HER2-IN-14

😃Good
Catalog No. T88221Cas No. 3034701-54-4
EGFR/HER2-IN-14 (Compd 46) serves as an inhibitor for drug-resistant mutant EGFR/HER2s. This compound is utilized in cancer research.
Pack SizePriceAvailabilityQuantity
10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
EGFR/HER2-IN-14 (Compd 46) serves as an inhibitor for drug-resistant mutant EGFR/HER2s. This compound is utilized in cancer research.
In vitro
EGFR/HER2-IN-14 exhibits an IC50 of less than 100 nM in Ba/F3 cells transfected with EGFR exon 20 insASV/insSVD and HER2 exon 20 insGSP/insYVMA mutations [1].
Chemical Properties
Molecular Weight575.62
FormulaC32H29N7O4
Cas No.3034701-54-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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