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EGFR-IN-112

Catalog No. T88058Cas No. 2758436-98-3

EGFR-IN-112 (SPP10), an EGFR kinase inhibitor, displays IC50 values of 2.31 ± 0.3 μM for MCF-7, 3.16 ± 0.8 μM for H69AR, and 4.2 ± 0.2 μM for PC-3 cancer cells, showcasing selective cytotoxicity towards these cancer cell lines.

EGFR-IN-112

EGFR-IN-112

Catalog No. T88058Cas No. 2758436-98-3
EGFR-IN-112 (SPP10), an EGFR kinase inhibitor, displays IC50 values of 2.31 ± 0.3 μM for MCF-7, 3.16 ± 0.8 μM for H69AR, and 4.2 ± 0.2 μM for PC-3 cancer cells, showcasing selective cytotoxicity towards these cancer cell lines.
Pack SizePriceAvailabilityQuantity
10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
EGFR-IN-112 (SPP10), an EGFR kinase inhibitor, displays IC50 values of 2.31 ± 0.3 μM for MCF-7, 3.16 ± 0.8 μM for H69AR, and 4.2 ± 0.2 μM for PC-3 cancer cells, showcasing selective cytotoxicity towards these cancer cell lines.
In vitro
EGFR-IN-112 (IC 50, 72 h) significantly inhibits Bcl-2 in MCF-7, H69AR, and PC-3 cells, while simultaneously inducing Bax and Cyt-c [1].
Chemical Properties
Molecular Weight421.56
FormulaC27H23N3S
Cas No.2758436-98-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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