ELOVL6-IN-4

ELOVL6-IN-4 is a potent and selective long chain fatty acid elongase 6 (ELOVL6) inhibitor that is orally active, with IC50 values of 79 nM for human ELOVL6 and 94 nM for mouse ELOVL6. It demonstrates excellent selectivity over other human ELOVL subtypes (ELOVL1, -2, -3, and -5) and mouse ELOVL3 [1].

Catalog No. T86362Cas No. 1170321-92-2

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ELOVL6-IN-4

Catalog No. T86362Cas No. 1170321-92-2

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Pack Size	Price	Availability	Quantity
10 mg	Inquiry	10-14 weeks
50 mg	Inquiry	10-14 weeks

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Product Introduction

Bioactivity

Description	ELOVL6-IN-4 is a potent and selective long chain fatty acid elongase 6 (ELOVL6) inhibitor that is orally active, with IC50 values of 79 nM for human ELOVL6 and 94 nM for mouse ELOVL6. It demonstrates excellent selectivity over other human ELOVL subtypes (ELOVL1, -2, -3, and -5) and mouse ELOVL3 [1].
In vitro	ELOVL6-IN-4 (compound 1w) effectively reduces the elongation index in mouse hepatocytes H2.35, with an IC₅₀ of 30 nM.
In vivo	ELOVL6-IN-4 (compound 1w; 1-10 mg/kg; oral administration, single dose) effectively and dose-dependently inhibits the elongation index in the liver of male C57BL/6J mice [1]. Dosage: 1 mg/kg, 3 mg/kg, and 10 mg/kg; Administration: Oral, single dose. Result: Significant inhibition of hepatic elongation index.

Chemical Properties

Molecular Weight	439.45
Formula	C₂₀H₂₀F₃N₃O₃S
Cas No.	1170321-92-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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