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EMI56

Name: EMI56
Brand: TargetMol
SKU: T35913
Price: 30 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T35913Cas No. 2414374-41-5

EMI56, a derivative of EMI1, exhibits enhanced potency against mutant EGFR compared to EMI1. Additionally, EMI56 effectively inhibits EGFR triple mutants[1].

EMI56

Catalog No. T35913Cas No. 2414374-41-5

EMI56, a derivative of EMI1, exhibits enhanced potency against mutant EGFR compared to EMI1. Additionally, EMI56 effectively inhibits EGFR triple mutants[1].

Pack Size	Price	Availability
2 mg	$233	5 days
5 mg	$297	5 days
25 mg	$916	6-8 weeks
50 mg	$1,190	6-8 weeks
100 mg	$1,860	6-8 weeks
1 mL x 10 mM (in DMSO)	$318	5 days

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	EMI56, a derivative of EMI1, exhibits enhanced potency against mutant EGFR compared to EMI1. Additionally, EMI56 effectively inhibits EGFR triple mutants[1].
In vitro	EMI56 inhibits EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S and can be used in research of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC)[1]. EMI56 (10, 15, 20 μM; 2 h of treatment) strongly inhibits total EGFR levels, activation, and downstream signaling in PC9 EGFR ex19del/T790M/C797S cells[1].

Chemical Properties

Molecular Weight	348.4
Formula	C₂₁H₂₀N₂O₃
Cas No.	2414374-41-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (143.51 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8703 mL	14.3513 mL	28.7026 mL	143.5132 mL
5 mM	0.5741 mL	2.8703 mL	5.7405 mL	28.7026 mL
10 mM	0.2870 mL	1.4351 mL	2.8703 mL	14.3513 mL
20 mM	0.1435 mL	0.7176 mL	1.4351 mL	7.1757 mL
50 mM	0.0574 mL	0.2870 mL	0.5741 mL	2.8703 mL
100 mM	0.0287 mL	0.1435 mL	0.2870 mL	1.4351 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

EMI 56EMI56EMI-56