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Enalaprilat
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Catalog No. T6340LCas No. 76420-72-9
Alias MK-422, MK422, MK 421 diacid, Enalapril acid
Enalaprilat (Enalapril acid) is a potent angiotensin-converting enzyme (ACE) inhibitor that enhances arterial and cardiopulmonary pressure reflex control of sympathetic activity in patients with heart failure, and can be used in the study of cardiovascular disease.
Enalaprilat
😃Good
Catalog No. T6340LAlias MK-422, MK422, MK 421 diacid, Enalapril acidCas No. 76420-72-9
Enalaprilat (Enalapril acid) is a potent angiotensin-converting enzyme (ACE) inhibitor that enhances arterial and cardiopulmonary pressure reflex control of sympathetic activity in patients with heart failure, and can be used in the study of cardiovascular disease.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $62 | In Stock | |
| 10 mg | $93 | In Stock | |
| 25 mg | $158 | In Stock | |
| 50 mg | $238 | 7-10 days | |
| 100 mg | $357 | 7-10 days |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Enalaprilat (Enalapril acid) is a potent angiotensin-converting enzyme (ACE) inhibitor that enhances arterial and cardiopulmonary pressure reflex control of sympathetic activity in patients with heart failure, and can be used in the study of cardiovascular disease. |
| Targets&IC50 | IGF-I-induced proliferation of neonatal cardiac fibroblasts (rat):90 nM, ACE:1.94 nM |
| In vitro | Enalaprilat, the active metabolite of the orally administered drug enalapril, exhibits potent, competitive and long-lasting angiotensin-converting enzyme (ACE) inhibition with an IC50 of 1.94 nM.[1] Enalaprilat (1 nM-10 μM; 24 hours) inhibited IGF-I-induced proliferation of neonatal rat cardiac fibroblasts by 30% in a concentration-dependent manner with an IC50 of 90 nM.[2] |
| In vivo | Enalaprilat (0.01%-2.9% ophthalmic concentration) showed significant IOP-lowering effect in rabbit IOP assay. [3] |
| Alias | MK-422, MK422, MK 421 diacid, Enalapril acid |
| Molecular Weight | 348.39 |
| Formula | C18H24N2O5 |
| Cas No. | 76420-72-9 |
| Smiles | C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C)(=O)N2[C@H](C(O)=O)CCC2 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80.00 mg/mL (229.63 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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