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EV-A71-IN-1 is a potent inhibitor of the human enterovirus A71 (EV-A71) capsid protein, with an EC50 of 0.27 μM against EV-A71. Acting as a capsid binder, EV-A71-IN-1 disrupts the crucial interaction between the viral VP1 protein and the host receptor hSCARB2. It displays broad-spectrum antiviral activity against various human enteroviruses, while being non-toxic to human cells (CC50 > 56.2 μM) [1].
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | 1.444 € | 6-8 weeks | |
50 mg | 1.881 € | 6-8 weeks | |
100 mg | 2.375 € | 6-8 weeks |
Description | EV-A71-IN-1 is a potent inhibitor of the human enterovirus A71 (EV-A71) capsid protein, with an EC50 of 0.27 μM against EV-A71. Acting as a capsid binder, EV-A71-IN-1 disrupts the crucial interaction between the viral VP1 protein and the host receptor hSCARB2. It displays broad-spectrum antiviral activity against various human enteroviruses, while being non-toxic to human cells (CC50 > 56.2 μM) [1]. |
In vitro | EV-A71-IN-1 (compound 12s) exhibits efficacy across various EV-A71 strains (BrCr, GZ-CII, EV71/HeN09, and EV71/G082) and extends its antiviral activity to other notable enteroviruses including CV-A16, EV-D68, Echov-6, CV-B2, and CV-B6 [1]. |
Molecular Weight | 369.44 |
Formula | C21H15N5S |
Cas No. | 2413648-96-9 |
Storage | Shipping with blue ice. |
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