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Frunevetmab
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Catalog No. T78316Cas No. 1708936-80-4
Alias NV-02
Frunevetmab (NV-02), a felinized monoclonal antibody targeting nerve growth factor (NGF), exhibits a high affinity with a dissociation constant (Kd) of 20 pM and has been demonstrated to effectively mitigate osteoarthritis (OA) pain in cats [1] [2].
Frunevetmab
Frunevetmab
😃Good
Catalog No. T78316Alias NV-02Cas No. 1708936-80-4
Frunevetmab (NV-02), a felinized monoclonal antibody targeting nerve growth factor (NGF), exhibits a high affinity with a dissociation constant (Kd) of 20 pM and has been demonstrated to effectively mitigate osteoarthritis (OA) pain in cats [1] [2].
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| 5 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Frunevetmab (NV-02), a felinized monoclonal antibody targeting nerve growth factor (NGF), exhibits a high affinity with a dissociation constant (Kd) of 20 pM and has been demonstrated to effectively mitigate osteoarthritis (OA) pain in cats [1] [2]. |
| In vitro | Frunevetmab (NV-02) neutralizes nerve growth factor (NGF) with high affinity and potency without binding to the complement system [2]. |
| In vivo | Frunevetmab administered subcutaneously at a dosage of 1.0-2.8mg/kg on days 0, 28, and 56 demonstrated a positive therapeutic effect on cats with naturally occurring osteoarthritis, alleviating pain and improving associated mobility impairments and disabilities [1]. |
| Alias | NV-02 |
| Cas No. | 1708936-80-4 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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