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FW1256

Name: FW1256
Brand: TargetMol
SKU: T15361
Rating: 4.5 (1 reviews)

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Catalog No. T15361Cas No. 117089-08-4

FW1256 is a phenyl analog. It also a slow-releasing hydrogen sulfide (H2S) donor. FW1256 inhibits NF-κB activity and causes cell apoptosis. FW1256 shows potent anti-inflammatory effects. It also has the potential for cancer and cardiovascular disease treatment.

FW1256

😃Good

Catalog No. T15361Cas No. 117089-08-4

Pack Size	Price	Availability
25 mg	$1,430	6-8 weeks
50 mg	$1,860	6-8 weeks
100 mg	$2,500	6-8 weeks

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

Product Introduction

Bioactivity

Description	FW1256 is a phenyl analog. It also a slow-releasing hydrogen sulfide (H2S) donor. FW1256 inhibits NF-κB activity and causes cell apoptosis. FW1256 shows potent anti-inflammatory effects. It also has the potential for cancer and cardiovascular disease trea
In vitro	FW1256 (200 μM; 24.5 hours; AW264.7 cells) treatment obviously decreases IL-1β, COX-2, iNOS PROTE, and iNOS mRNA and protein in LPS-stimulated RAW264.7 macrophages. FW1256 reduces NF-κB activation as evidenced by reduced cytosolic phospho-IκBα levels and reduces nuclear p65 levels in LPS-stimulated RAW264.7 macrophages treated with FW1256. FW1256 concentration-dependently reduces TNF-α (IC50: 61.2 μM), IL-6 (IC50: 11.7 μM), PGE2 (IC50: 25.5 μM) and NO (IC50: 34.6 μM) generation in LPS-stimulated RAW264.7 macrophages and bone marrow-derived macrophages (BMDMs) (IC50s: 414.9 μM, 300.2 μM, 4 μM and 9.5 μM for TNF-α, IL-6, PGE2 and NO, respectively) [1].
In vivo	Treatment with FW1256 (100 mg/kg; i.p.; male C57BL/6 mice), decreases IL-1β, TNFα, nitrate/nitrite, and PGE2 levels in LPS-treated mice [1].

Chemical Properties

Molecular Weight	247.25
Formula	C₁₂H₁₀NOPS
Cas No.	117089-08-4
Relative Density.	1.37 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 250 mg/mL (1011.12 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0445 mL	20.2224 mL	40.4449 mL	202.2245 mL
5 mM	0.8089 mL	4.0445 mL	8.0890 mL	40.4449 mL
10 mM	0.4044 mL	2.0222 mL	4.0445 mL	20.2224 mL
20 mM	0.2022 mL	1.0111 mL	2.0222 mL	10.1112 mL
50 mM	0.0809 mL	0.4044 mL	0.8089 mL	4.0445 mL
100 mM	0.0404 mL	0.2022 mL	0.4044 mL	2.0222 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

FW-1256FW1256FW 1256