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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | Inquiry | 10-14 weeks | |
50 mg | Inquiry | 10-14 weeks |
Description | Galectin-3-IN-4 (compound 5), a carboxamide analog, effectively and selectively inhibits both human and mouse galectin-3. This compound demonstrates notable potency with IC50 values of 21 nM for hGal-3 and 167 nM for mGal-3. It is also orally bioavailable. For other galectins, Galectin-3-IN-4 shows IC50 values of 1580 nM for hGal-1 and 2750 nM for hGal-9, respectively [1]. |
Targets&IC50 | Galectin-1:1580 nM, Galectin-3:21 nM, Galectin-3:167 nM |
In vivo | Galectin-3-IN-4 (compound 5) demonstrates low clearance (CL=12 mL/min/kg) and a high volume of distribution (Vss=2.1 L/kg). When administered to mice, it shows an oral bioavailability of 52% [1] at doses of 2 mg/kg intravenously and 10 mg/kg orally, given once. |
Molecular Weight | 565.98 |
Formula | C24H22ClF2N5O5S |
Cas No. | 2496515-38-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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