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gamma-Secretase Modulators

gamma-Secretase Modulators
gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β. Specifically, it acts as a gamma-Secretase Modulators with an IC50 value.
Catalog No. T11362Cas No. 937812-80-1
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gamma-Secretase Modulators

Catalog No. T11362Cas No. 937812-80-1
gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β. Specifically, it acts as a gamma-Secretase Modulators with an IC50 value.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
25 mg$1,93010-14 weeks
50 mg$2,51010-14 weeks
100 mg$3,81010-14 weeks
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Product Introduction

Bioactivity
Description
gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β. Specifically, it acts as a gamma-Secretase Modulators with an IC50 value.
Aliasγ-Secretase Modulators, Amyloid-β production inhibitor
Chemical Properties
Molecular Weight483.48
FormulaC26H24F3N3O3
Cas No.937812-80-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (206.83 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0683 mL10.3417 mL20.6834 mL103.4169 mL
5 mM0.4137 mL2.0683 mL4.1367 mL20.6834 mL
10 mM0.2068 mL1.0342 mL2.0683 mL10.3417 mL
20 mM0.1034 mL0.5171 mL1.0342 mL5.1708 mL
50 mM0.0414 mL0.2068 mL0.4137 mL2.0683 mL
100 mM0.0207 mL0.1034 mL0.2068 mL1.0342 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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