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Gevokizumab

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Catalog No. T76731Cas No. 1129435-60-4

Gevokizumab, a powerful anti-IL-1β antibody, inhibits IL-1β signaling allosterically, effectively reducing IL-1β's binding affinity for its IL-1 receptor type I (IL-1RI) signaling receptor, while not affecting its interaction with the IL-1 counter-regulatory decoy receptor (IL-1 receptor type II) [1] [2].

Gevokizumab

Gevokizumab

😃Good
Catalog No. T76731Cas No. 1129435-60-4
Gevokizumab, a powerful anti-IL-1β antibody, inhibits IL-1β signaling allosterically, effectively reducing IL-1β's binding affinity for its IL-1 receptor type I (IL-1RI) signaling receptor, while not affecting its interaction with the IL-1 counter-regulatory decoy receptor (IL-1 receptor type II) [1] [2].
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Bioactivity
Description
Gevokizumab, a powerful anti-IL-1β antibody, inhibits IL-1β signaling allosterically, effectively reducing IL-1β's binding affinity for its IL-1 receptor type I (IL-1RI) signaling receptor, while not affecting its interaction with the IL-1 counter-regulatory decoy receptor (IL-1 receptor type II) [1] [2].
Chemical Properties
Cas No.1129435-60-4
Storage & Solubility Information
StorageShipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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