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GLPG-3221

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Catalog No. T13704Cas No. 2222264-64-2

GLPG-3221 can be uesd for the treatment of cystic fibrosis.GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM.

GLPG-3221

GLPG-3221

😃Good
Catalog No. T13704Cas No. 2222264-64-2
GLPG-3221 can be uesd for the treatment of cystic fibrosis.GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM.
Pack SizePriceAvailabilityQuantity
25 mg$1,5206-8 weeks
50 mg$1,9806-8 weeks
100 mg$2,5006-8 weeks
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Product Introduction

Bioactivity
Description
GLPG-3221 can be uesd for the treatment of cystic fibrosis.GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM.
In vivo
GLPG-3221 (1 mg/kg; p.o.) demonstrates an F% of 53%, while GLPG-3221 (1 mg/kg; i.v.) exhibits a Cl of 0.13 L/h/kg and t1/2 of 3 hours.
Chemical Properties
Molecular Weight578.62
FormulaC30H37F3N2O6
Cas No.2222264-64-2
Relative Density.1.29 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

GLPG 3221GLPG3221GLPG-3221
Related Tags: buy GLPG-3221 | purchase GLPG-3221 | GLPG-3221 cost | order GLPG-3221 | GLPG-3221 chemical structure | GLPG-3221 in vivo | GLPG-3221 formula | GLPG-3221 molecular weight
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