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Grisnilimab setaritox

Name: Grisnilimab setaritox
Brand: TargetMol
SKU: T82259
Price: 64 EUR
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T82259Cas No. 2361013-29-6

Alias WT1-RTA

Grisnilimab setaritox (WT1-RTA), an anti-CD7 antihuman T cell antibody linked to ricin A chain (RTA), exhibits in vitro cytotoxicity against CEM (T-lymphoblastic leukemia) cells with an ID 50 of 53 pM. The 30-kDa RTA component disrupts the function of 60S ribosomal subunits. Additionally, Grisnilimab setaritox has demonstrated efficacy in ameliorating leukemic meningitis in a rhesus monkey model [1].

Grisnilimab setaritox

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Catalog No. T82259Alias WT1-RTACas No. 2361013-29-6

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Product Introduction

Bioactivity

Description	Grisnilimab setaritox (WT1-RTA), an anti-CD7 antihuman T cell antibody linked to ricin A chain (RTA), exhibits in vitro cytotoxicity against CEM (T-lymphoblastic leukemia) cells with an ID 50 of 53 pM. The 30-kDa RTA component disrupts the function of 60S ribosomal subunits. Additionally, Grisnilimab setaritox has demonstrated efficacy in ameliorating leukemic meningitis in a rhesus monkey model [1].
In vitro	Grisnilimab setaritox (2.5 μg/mL; 24 h) exhibits cytotoxicity against T-lymphoblastic leukemia CEM cells [1].
In vivo	Grisnilimab setaritox (60 μg, 120 μg; intrathecal or intravenous injection; single dose) demonstrated potential in inhibiting T-ALL meningeal leukemia in a rhesus macaque model [1]. Additionally, grisnilimab setaritox (60 μg; intravenous injection; once weekly for six weeks, or daily for seven days) induced CSF granulocytosis and anti-immunotoxin antibodies in the same model [1].
Alias	WT1-RTA

Chemical Properties

Cas No.

2361013-29-6

Storage & Solubility Information

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Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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