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GSK726701A

GSK726701A
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GSK726701A

Catalog No. T11499Cas No. 945721-87-9
GSK726701A is a new type of prostaglandin E2 receptor 4 (EP4) partial agonist (pEC50: 7.4).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
25 mg$1,8208-10 weeks
50 mg$2,3808-10 weeks
100 mg$3,1008-10 weeks
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Product Introduction

Bioactivity
Description
GSK726701A is a new type of prostaglandin E2 receptor 4 (EP4) partial agonist (pEC50: 7.4).
In vitro
GSK726701A has high selectivity (>100-fold) against a set of other prostaglandin receptors (EP1-3 , DP1 , FP, IP, TP) and no significant activity against a wider panel of targets.
In vivo
GSK726701A exhibits robust efficacy in various animal models for both inflammatory and neuropathic pain. Demonstrating time-dependent, complete reversal of CCI-induced mechanical allodynia at a dosage of 3mg/kg, GSK726701A matches the efficacy of the clinically acclaimed gabapentin, administered at 30mg/kg. Additionally, GSK726701A possesses an ED50 value of 0.2mg/kg in the FCA acute rat model of inflammatory pain, and showcases favorable pharmacokinetics across rat, dog, and monkey studies.
Chemical Properties
Molecular Weight423.43
FormulaC24H22FNO5
Cas No.945721-87-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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