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GSK726701A
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Catalog No. T11499Cas No. 945721-87-9
GSK726701A is a new type of prostaglandin E2 receptor 4 (EP4) partial agonist (pEC50: 7.4).
GSK726701A
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Catalog No. T11499Cas No. 945721-87-9
GSK726701A is a new type of prostaglandin E2 receptor 4 (EP4) partial agonist (pEC50: 7.4).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,820 | 8-10 weeks | |
| 50 mg | $2,380 | 8-10 weeks | |
| 100 mg | $3,100 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | GSK726701A is a new type of prostaglandin E2 receptor 4 (EP4) partial agonist (pEC50: 7.4). |
| In vitro | GSK726701A demonstrates high selectivity (>100-fold) for its target prostaglandin receptors (EP1-3, DP1, FP, IP, TP) and exhibits no significant activity against a broader range of other targets. |
| In vivo | GSK726701A exhibits robust efficacy in various animal models for both inflammatory and neuropathic pain. Demonstrating time-dependent, complete reversal of CCI-induced mechanical allodynia at a dosage of 3mg/kg, GSK726701A matches the efficacy of the clinically acclaimed gabapentin, administered at 30mg/kg. Additionally, GSK726701A possesses an ED50 value of 0.2mg/kg in the FCA acute rat model of inflammatory pain, and showcases favorable pharmacokinetics across rat, dog, and monkey studies. |
| Molecular Weight | 423.43 |
| Formula | C24H22FNO5 |
| Cas No. | 945721-87-9 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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