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GW311616

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GW311616

Catalog No. T11525Cas No. 198062-54-3

GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).

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Pack Size	Price	Availability
25 mg	Inquiry	10-14 weeks
50 mg	Inquiry	10-14 weeks
100 mg	Inquiry	10-14 weeks

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Product Introduction

Bioactivity

Description	GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).
Targets&IC50	HNE:(ki)0.31 nM , HNE:22 nM
In vitro	GW-311616 (150 μM;?U937 cells) treatment can increase the protein expression levels of Bax and decrease the expression of Bcl-2.GW-311616 (150 μM; 48 hours) markedly suppresses NE activity in U937 and K562 cells lines. GW-311616 (20-320 μM; 48 hours; U937 cells) treatment inhibits proliferation and induces apoptosis in leukemia cells.
In vivo	GW-311616 has moderate terminal elimination half-life (t1/2) of 1.1 hours and 1.5 hours for dog (2 mg/kg, oral), rat (2 mg/kg, oral), respectively.GW-311616 (2 mg/kg;?oral administration) rapidly abolishes the circulation of neutrophil elastase (NE) in dogs, while >90% inhibition is maintained for 4 days.?This prolonged effect is independent to be due to penetration of neutrophils in bone marrow by orally administrated GW-311616.

Chemical Properties

Molecular Weight	397.53
Formula	C19H31N3O4S
Cas No.	198062-54-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 44 mg/mL (110.68 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5155 mL	12.5777 mL	25.1553 mL	125.7767 mL
5 mM	0.5031 mL	2.5155 mL	5.0311 mL	25.1553 mL
10 mM	0.2516 mL	1.2578 mL	2.5155 mL	12.5777 mL
20 mM	0.1258 mL	0.6289 mL	1.2578 mL	6.2888 mL
50 mM	0.0503 mL	0.2516 mL	0.5031 mL	2.5155 mL
100 mM	0.0252 mL	0.1258 mL	0.2516 mL	1.2578 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

GW 311616GW311616GW-311616