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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 10-14 weeks | |
50 mg | $1,980 | 10-14 weeks | |
100 mg | $2,500 | 10-14 weeks |
Description | HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects. HIF-1α-IN-4 downregulates VEGF and PDK1 mRNA expressions under hypoxia [1]. |
In vitro | HIF-1α-IN-4 (compound 31, 24h) demonstrates inhibitory activity on HIF-1α transcription in HEK293T cells, exhibiting an IC50 of 24 nM [1]. Additionally, at concentrations ranging from 0-50 μM over 24 hours, it dose-dependently diminishes the expressions of VEGF and PDK1 mRNA in HEK293T cells under hypoxic conditions, as evidenced by RT-PCR [1]. |
Molecular Weight | 280.28 |
Formula | C16H12N2O3 |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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