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HPK1-IN-2 dihydrochloride

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Catalog No. T84714Cas No. 2375595-72-3

HPK1-IN-2 dihydrochloride, a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1) with an IC 50 of less than 0.05 µM, demonstrates significant antitumor activity. It additionally exhibits inhibition of Lck kinase activity, with an IC 50 ranging from 0.05 to less than 0.5 µM, and Flt3 kinase activity, with an IC 50 of less than 0.05 µM [1].

HPK1-IN-2 dihydrochloride
Other Forms of HPK1-IN-2 dihydrochloride:
HPK1-IN-2T90172056122-11-1
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HPK1-IN-2 dihydrochloride

😃Good
Catalog No. T84714Cas No. 2375595-72-3
HPK1-IN-2 dihydrochloride, a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1) with an IC 50 of less than 0.05 µM, demonstrates significant antitumor activity. It additionally exhibits inhibition of Lck kinase activity, with an IC 50 ranging from 0.05 to less than 0.5 µM, and Flt3 kinase activity, with an IC 50 of less than 0.05 µM [1].
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Product Introduction

Bioactivity
Description
HPK1-IN-2 dihydrochloride, a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1) with an IC 50 of less than 0.05 µM, demonstrates significant antitumor activity. It additionally exhibits inhibition of Lck kinase activity, with an IC 50 ranging from 0.05 to less than 0.5 µM, and Flt3 kinase activity, with an IC 50 of less than 0.05 µM [1].
In vitro
In a-CD3-stimulated Jurkat E6.1 cells, HPK1-IN-2 (example A1) suppresses the phosphorylation of SLP76 at serine 376 and ERK1/2 at T202/Y204, achieving IC50 values of 0.3-1 µM and >3µM, respectively [1].
Chemical Properties
Molecular Weight453.39
FormulaC19H22Cl2N6OS
Cas No.2375595-72-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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