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HRS-4642

Catalog No. T88678Cas No. 3033864-81-9

HRS-4642 is a selective KRAS(G12D) inhibitor (Kd=0.083 nM) with anticancer activity. It demonstrates significant in vivo efficacy in combination with Carfilzomib, synergistically remodeling the tumor microenvironment into an immune-activating one.

HRS-4642

HRS-4642

Catalog No. T88678Cas No. 3033864-81-9
HRS-4642 is a selective KRAS(G12D) inhibitor (Kd=0.083 nM) with anticancer activity. It demonstrates significant in vivo efficacy in combination with Carfilzomib, synergistically remodeling the tumor microenvironment into an immune-activating one.
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Product Introduction

Bioactivity
Description
HRS-4642 is a selective KRAS(G12D) inhibitor (Kd=0.083 nM) with anticancer activity. It demonstrates significant in vivo efficacy in combination with Carfilzomib, synergistically remodeling the tumor microenvironment into an immune-activating one.
Targets&IC50
KRas G12D:0.083 nM (Ki)
Chemical Properties
Molecular Weight634.69
FormulaC34H37F3N6O3
Cas No.3033864-81-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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