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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $970 | Backorder |
Description | IDO1-IN-7, a potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, exhibits high potency with an IC 50 of 6.1 nM in the cellular assay (SKOV3). Apart from its inhibitory properties, IDO1-IN-7 also demonstrates immunomodulatory effects, contributing to its potential applications in cancer research. |
Targets&IC50 | IDO1 (SKOV3 cells):6.1 nM (IC50) |
In vitro | IDO1-IN-7 demonstrates moderate effectiveness in inhibiting target activity in a human whole blood assay, achieving an IC50 of 330 nM[1]. It also exhibits a favorable profile, characterized by good metabolic stability and satisfactory off-target selectivity[1]. Moreover, IDO1-IN-7 displays high specificity for IDO1, significantly outperforming tryptophan 2,3-dioxygenase (TDO) with an IC50 of 14,000 nM, highlighting its selectivity[1]. |
In vivo | IDO1-IN-7, administered orally at a dosage of 10 mg/kg, demonstrates a maximal concentration (C max) of 10.0 μM and an area under the curve (AUC) from 0 to 8 hours of 27.1 μM*h, with a half-life (t 1/2) of 1.4 hours in mice. [1] This pharmacokinetic analysis was conducted in a mouse model. |
Alias | IDO1-IN-7 |
Molecular Weight | 427.86 |
Formula | C22H19ClFN3O3 |
Cas No. | 2351199-98-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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