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iHCK-37
🥰Excellent
Catalog No. T40594Cas No. 516478-09-4
Alias ASN05260065, ASN 05260065
iHCK-37 (ASN05260065) is a selective Hck inhibitor with antitumor activity, blocking HIV-1 viral replication. iHCK-37 reduces PI3K/AKT and MAPK/ERK pathway activation after erythropoietin induction in high Hck-expressing cells, useful in chronic myelogenous leukemia (CML) research.
iHCK-37
🥰Excellent
Purity: 99.97%
Catalog No. T40594Alias ASN05260065, ASN 05260065Cas No. 516478-09-4
iHCK-37 (ASN05260065) is a selective Hck inhibitor with antitumor activity, blocking HIV-1 viral replication. iHCK-37 reduces PI3K/AKT and MAPK/ERK pathway activation after erythropoietin induction in high Hck-expressing cells, useful in chronic myelogenous leukemia (CML) research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $132 | In Stock | |
| 5 mg | $329 | In Stock | |
| 10 mg | $519 | In Stock | |
| 25 mg | $980 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $362 | In Stock |
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Purity:99.97%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | iHCK-37 (ASN05260065) is a selective Hck inhibitor with antitumor activity, blocking HIV-1 viral replication. iHCK-37 reduces PI3K/AKT and MAPK/ERK pathway activation after erythropoietin induction in high Hck-expressing cells, useful in chronic myelogenous leukemia (CML) research. |
| Targets&IC50 | Hck:0.22 μM (Ki) |
| In vitro | Methods: AML cell lines (HL60, KG1a and U937) and chronic myeloid leukemia cell lines (HEL and K562) were treated with iHCK-37 (5.0-20 μM, 24 hours) and cell viability was detected. Results: iHCK-37 showed effective antiproliferative activity in vitro, with growth inhibition (GI50) of 5.0-5.8 μM for AML cell lines (HL60, KG1a and U937) and 9.1-19.2 μM for chronic myeloid leukemia cell lines (HEL and K562). [2] Methods: Lentivirus HCK-silenced K562 and U937 cell lines and KG1a (AML/CD34+) cell lines were treated with iHCK-37 (3-9 μM) and protein level changes were detected by WB. Results: iHCK-37 led to decreased phosphorylation of ERK, AKT, and P70S6K in lentiviral HCK-silenced K562 and U937 cell lines; and decreased p-HCK, p-ERK, p-AKT, and p-70S6 in the KG1a (AML/CD34+) cell line in a concentration-dependent manner. [2] |
| Alias | ASN05260065, ASN 05260065 |
| Molecular Weight | 544.73 |
| Formula | C30H32N4O2S2 |
| Cas No. | 516478-09-4 |
| Smiles | O=C(NC=1C=CC=CC1N2CCOCC2)CSC=3N=C(N=C4SC5=C(C43)CCCC5)CCC=6C=CC=CC6 |
| Relative Density. | 1.34 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 200 mg/mL (367.15 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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