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iHCK-37 (ASN05260065) is a selective Hck inhibitor with antitumor activity, blocking HIV-1 viral replication. iHCK-37 reduces PI3K/AKT and MAPK/ERK pathway activation after erythropoietin induction in high Hck-expressing cells, useful in chronic myelogenous leukemia (CML) research.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $198 | In Stock | |
5 mg | $513 | In Stock | |
10 mg | $738 | In Stock | |
25 mg | $1,150 | In Stock | |
50 mg | $1,550 | In Stock | |
100 mg | $1,980 | In Stock | |
200 mg | $2,820 | In Stock |
Description | iHCK-37 (ASN05260065) is a selective Hck inhibitor with antitumor activity, blocking HIV-1 viral replication. iHCK-37 reduces PI3K/AKT and MAPK/ERK pathway activation after erythropoietin induction in high Hck-expressing cells, useful in chronic myelogenous leukemia (CML) research. |
Targets&IC50 | Hck:0.22 μM (Ki) |
In vitro | Methods: AML cell lines (HL60, KG1a and U937) and chronic myeloid leukemia cell lines (HEL and K562) were treated with iHCK-37 (5.0-20 μM, 24 hours) and cell viability was detected. Results: iHCK-37 showed effective antiproliferative activity in vitro, with growth inhibition (GI50) of 5.0-5.8 μM for AML cell lines (HL60, KG1a and U937) and 9.1-19.2 μM for chronic myeloid leukemia cell lines (HEL and K562). [2] Methods: Lentivirus HCK-silenced K562 and U937 cell lines and KG1a (AML/CD34+) cell lines were treated with iHCK-37 (3-9 μM) and protein level changes were detected by WB. Results: iHCK-37 led to decreased phosphorylation of ERK, AKT, and P70S6K in lentiviral HCK-silenced K562 and U937 cell lines; and decreased p-HCK, p-ERK, p-AKT, and p-70S6 in the KG1a (AML/CD34+) cell line in a concentration-dependent manner. [2] |
Alias | ASN05260065, ASN 05260065 |
Molecular Weight | 544.73 |
Formula | C30H32N4O2S2 |
Cas No. | 516478-09-4 |
Smiles | O=C(NC=1C=CC=CC1N2CCOCC2)CSC=3N=C(N=C4SC5=C(C43)CCCC5)CCC=6C=CC=CC6 |
Relative Density. | 1.34 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 200 mg/mL (367.15 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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