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iHCK-37

🥰Excellent
Catalog No. T40594Cas No. 516478-09-4
Alias ASN05260065, ASN 05260065

iHCK-37 (ASN05260065) is a selective Hck inhibitor with antitumor activity, blocking HIV-1 viral replication. iHCK-37 reduces PI3K/AKT and MAPK/ERK pathway activation after erythropoietin induction in high Hck-expressing cells, useful in chronic myelogenous leukemia (CML) research.

iHCK-37

iHCK-37

🥰Excellent
Purity: 99.97%
Catalog No. T40594Alias ASN05260065, ASN 05260065Cas No. 516478-09-4
iHCK-37 (ASN05260065) is a selective Hck inhibitor with antitumor activity, blocking HIV-1 viral replication. iHCK-37 reduces PI3K/AKT and MAPK/ERK pathway activation after erythropoietin induction in high Hck-expressing cells, useful in chronic myelogenous leukemia (CML) research.
Pack SizePriceAvailabilityQuantity
1 mg$198 In Stock
5 mg$513 In Stock
10 mg$738 In Stock
25 mg$1,150 In Stock
50 mg$1,550 In Stock
100 mg$1,980 In Stock
200 mg$2,820 In Stock
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Purity:99.97%
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Product Introduction

Bioactivity
Description
iHCK-37 (ASN05260065) is a selective Hck inhibitor with antitumor activity, blocking HIV-1 viral replication. iHCK-37 reduces PI3K/AKT and MAPK/ERK pathway activation after erythropoietin induction in high Hck-expressing cells, useful in chronic myelogenous leukemia (CML) research.
Targets&IC50
Hck:0.22 μM (Ki)
In vitro
Methods: AML cell lines (HL60, KG1a and U937) and chronic myeloid leukemia cell lines (HEL and K562) were treated with iHCK-37 (5.0-20 μM, 24 hours) and cell viability was detected.
Results: iHCK-37 showed effective antiproliferative activity in vitro, with growth inhibition (GI50) of 5.0-5.8 μM for AML cell lines (HL60, KG1a and U937) and 9.1-19.2 μM for chronic myeloid leukemia cell lines (HEL and K562). [2]
Methods: Lentivirus HCK-silenced K562 and U937 cell lines and KG1a (AML/CD34+) cell lines were treated with iHCK-37 (3-9 μM) and protein level changes were detected by WB.
Results: iHCK-37 led to decreased phosphorylation of ERK, AKT, and P70S6K in lentiviral HCK-silenced K562 and U937 cell lines; and decreased p-HCK, p-ERK, p-AKT, and p-70S6 in the KG1a (AML/CD34+) cell line in a concentration-dependent manner. [2]
AliasASN05260065, ASN 05260065
Chemical Properties
Molecular Weight544.73
FormulaC30H32N4O2S2
Cas No.516478-09-4
SmilesO=C(NC=1C=CC=CC1N2CCOCC2)CSC=3N=C(N=C4SC5=C(C43)CCCC5)CCC=6C=CC=CC6
Relative Density.1.34 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 200 mg/mL (367.15 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8358 mL9.1789 mL18.3577 mL91.7886 mL
5 mM0.3672 mL1.8358 mL3.6715 mL18.3577 mL
10 mM0.1836 mL0.9179 mL1.8358 mL9.1789 mL
20 mM0.0918 mL0.4589 mL0.9179 mL4.5894 mL
50 mM0.0367 mL0.1836 mL0.3672 mL1.8358 mL
100 mM0.0184 mL0.0918 mL0.1836 mL0.9179 mL

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