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Hck-IN-1
🥰Excellent
Catalog No. T11538Cas No. 1473404-51-1
Hck-IN-1 is a selective Nef-dependent Hck inhibitor (IC50s: 2.8 μM and >20 μM for Nef:Hck complex and Hck) with antiretroviral activity. Hck-IN-1 is a direct and wide HIV-1 Nef antagonist with an IC50 of 100-300 nM for wild-type HIV-1 replication.
Hck-IN-1
🥰Excellent
Purity: 99.07%
Catalog No. T11538Cas No. 1473404-51-1
Hck-IN-1 is a selective Nef-dependent Hck inhibitor (IC50s: 2.8 μM and >20 μM for Nef:Hck complex and Hck) with antiretroviral activity. Hck-IN-1 is a direct and wide HIV-1 Nef antagonist with an IC50 of 100-300 nM for wild-type HIV-1 replication.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $106 | In Stock | |
| 5 mg | $228 | In Stock | |
| 10 mg | $363 | In Stock | |
| 25 mg | $596 | In Stock | |
| 50 mg | $868 | In Stock | |
| 100 mg | $1,180 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $253 | In Stock |
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CitedSelect Batch
Purity:99.07%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Hck-IN-1 is a selective Nef-dependent Hck inhibitor (IC50s: 2.8 μM and >20 μM for Nef:Hck complex and Hck) with antiretroviral activity. Hck-IN-1 is a direct and wide HIV-1 Nef antagonist with an IC50 of 100-300 nM for wild-type HIV-1 replication. |
| Targets&IC50 | HIV-1 (Nef):100-300 nM |
| In vitro | Hck-IN-1 inhibits the replication of all eleven HIV-1 Nef chimeras (IC50s: ~ 300 nM in CEM-T4 cells) demonstrating that the compound is broadly active against HIV replication supported by a wide range of HIV-1 Nef proteins. Hck-IN-1 shows weak activity against other Src-family members in vitro, with IC50 values >20 μM for c-Src, Lck, and Lyn. B9 (1 μM; 8 days) completely inhibits Nef-dependent SFK activation at a concentration of 1.0 μM. Hck-IN-1 (0.1, 0.3, 1, 3 μM) also inhibits Nef-mediated enhancement of HIV-1 infectivity in a concentration-dependent manner in the reporter cell line, TZM-bl. |
| Molecular Weight | 402.81 |
| Formula | C16H11ClN6O3S |
| Cas No. | 1473404-51-1 |
| Smiles | NC(=S)n1nc(c(\N=N\c2cccc(Cl)c2)c1O)-c1ccc(cc1)[N+]([O-])=O |
| Relative Density. | 1.63 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 12.5 mg/mL (31.03 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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