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Ipragliflozin (L-Proline)
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Catalog No. T11667Cas No. 951382-34-6
Alias Ipragliflozin L-Proline
Ipragliflozin is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM; little and NO potency for SGLT1/3/4/5/6.
Ipragliflozin (L-Proline)
😃Good
Catalog No. T11667Alias Ipragliflozin L-ProlineCas No. 951382-34-6
Ipragliflozin is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM; little and NO potency for SGLT1/3/4/5/6.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $30 | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ipragliflozin is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM; little and NO potency for SGLT1/3/4/5/6. |
| Targets&IC50 | SGLT2:2.8 nM |
| In vitro | Ipragliflozin selectively and potently inhibits human, rat, and mouse SGLT2 at nanomolar ranges and exhibits stability against intestinal glucosidases. |
| In vivo | Following oral administration, ipragliflozin demonstrates favorable pharmacokinetic properties and dose-dependently enhances urinary glucose excretion, with effects lasting over 12 hours in normal mice. This increase in urinary glucose excretion is significant at doses of 0.3 mg/kg or higher. Additionally, a single dose of ipragliflozin effectively increases urinary glucose excretion, lowers blood glucose and plasma insulin levels, and ameliorates glucose intolerance. |
| Alias | Ipragliflozin L-Proline |
| Molecular Weight | 519.58 |
| Formula | C26H30FNO7S |
| Cas No. | 951382-34-6 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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