Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | IRAK inhibitor 4 is an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4). |
In vitro | IRAK1/4, at a concentration of 20 μM, suppresses LPS-induced IL-6 production but does not affect p38 phosphorylation in alveolar macrophages (AMs). Concurrently, the use of both IRAK1/4 and Rip2 inhibitors significantly reduces TLR2-mediated cytokine production in sarcoidosis patient-derived peripheral blood mononuclear cells (PBMCs) and AMs. Moreover, IRAK4 is found to be both overexpressed and activated in T-cell acute lymphoblastic leukemia (T-ALL), with IRAK4 mRNA levels being higher in T-ALL cells from patients compared to those in thymic T cells or peripheral blood T cells. Additionally, the absence of IRAK-4 compromises the ability of macrophages and dendritic cells (DCs) to produce pro-inflammatory mediators in response to M. bovis and M. tuberculosis. IRAK-4-deficient cells, when stimulated with E. coli LPS, show significantly slower activation kinetics across all signaling proteins examined and a marked decrease in p65 phosphorylation. |
In vivo | IRAK-4-/- mice demonstrate an elevated bacterial load across all organs at 15, 30, and 60 days post-infection. Moreover, MCL1, unlike BCL-xL, negates the therapeutic benefits of combined IRAK1/4 inhibitor and ABT-737 treatment in vivo. Additionally, these mice experience significantly decreased survival rates after aerosol infection compared to their IRAK-4+/+ or IRAK-4+/- counterparts. |
Molecular Weight | 620.66 |
Formula | C33H35F3N6O3 |
Cas No. | 1012104-68-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 12.5 mg/mL (20.14 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.