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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $970 | Backorder |
Description | JAK-2/3-IN-1 is a highly effective inhibitor targeting both JAK-2 and JAK-3 isoforms, exhibiting remarkable potency with Ki values below 250 nM for both isoforms. |
Targets&IC50 | JAK2:<250 nM (Ki), JAK3:<250 nM (Ki) |
In vitro | The Janus kinases (JAK), comprising JAK-1, JAK-2, JAK-3, and TYK-2, are essential tyrosine kinases in cytokine signaling, with their downstream targets including signal transducer and activator of transcription (STAT) proteins. The JAK/STAT pathway is crucial in mediating various aberrant immune responses, including allergies, asthma, autoimmune diseases, and both solid and hematologic malignancies[1]. |
Molecular Weight | 345.79 |
Formula | C20H12ClN3O |
Cas No. | 1036241-36-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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