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JAK1-IN-12

Name: JAK1-IN-12
Brand: TargetMol
SKU: T86756
Price: 693 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T86756Cas No. 2945204-95-3

JAK1-IN-12, a selective inhibitor of JAK1, exhibits an IC50 of 0.0246 μM and demonstrates IC50 values of 0.423 μM, 0.410 μM, and 1.12 μM for JAK2, JAK3, and TYK2, respectively. It promotes hair growth in mice and is applicable for researching immune and inflammatory diseases [1].

JAK1-IN-12

Catalog No. T86756Cas No. 2945204-95-3

Pack Size	Price	Availability	Quantity
10 mg	Inquiry	10-14 weeks
50 mg	Inquiry	10-14 weeks

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Product Introduction

Bioactivity

Description	JAK1-IN-12, a selective inhibitor of JAK1, exhibits an IC50 of 0.0246 μM and demonstrates IC50 values of 0.423 μM, 0.410 μM, and 1.12 μM for JAK2, JAK3, and TYK2, respectively. It promotes hair growth in mice and is applicable for researching immune and inflammatory diseases [1].
Targets&IC50	JAK3:0.410 μM, JAK2:0.423 μM, JAK1:0.0246 μM
In vitro	HDAC-IN-57 (Compound 12b) inhibits JAK1 and JAK2 in Ba/F3-TEL-JAK1 cell lines, with IC50 values of 0.110 μM and 6.105 μM, respectively [1]. At a concentration of 1 μM, HDAC-IN-57 (Compound 12b) exhibits strong interactions with JAK1, JAK3, PKD2, HPK1, and AurB in kinase panel assays [1].
In vivo	JAK1-IN-12 (Compound 12b) was administered as a 2% solution in 10% DMSO, applied daily for one month, to 8-week-old C57/B6 mice to enhance hair growth in the shaved dorsal back region [1]. Animal Model: C57/B6 mice [1] Dosage: 2% in 10% DMSO solution Administration: Topical application; daily for 1 month Result: Induced skin darkening within 9 days and stimulated new hair growth within 13 days.

Chemical Properties

Molecular Weight	349.43
Formula	C₂₀H₂₃N₅O
Cas No.	2945204-95-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc