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Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, with IC50 values of 77 nM in a fluorescence polarization (FP) assay and 2.5 nM in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay [1].
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 8-10 weeks | |
50 mg | $1,980 | 8-10 weeks | |
100 mg | $2,500 | 8-10 weeks |
Description | Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, with IC50 values of 77 nM in a fluorescence polarization (FP) assay and 2.5 nM in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay [1]. |
In vitro | Keap1-Nrf2-IN-15 (Compound 24a) binds to Keap1 protein [1] and, at concentrations of 10 and 100 μM for 24 hours, significantly induces the expression of Nrf2 target genes (HMOX1, GSTM3, NQO1) in NCM460D cells [1]. |
Molecular Weight | 801.84 |
Formula | C39H35N3O12S2 |
Cas No. | 2456295-45-5 |
Storage | Shipping with blue ice. |
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