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KHK-IN-1 hydrochloride

Name: KHK-IN-1 hydrochloride
Brand: TargetMol
SKU: T15659
Rating: 4.5 (1 reviews)

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Catalog No. T15659Cas No. 1303470-48-5

KHK-IN-1 hydrochloride is a selective, cell-permeable, and efficient hexokinase (KHK) inhibitor, useful for studying diabetes and obesity.

KHK-IN-1 hydrochloride

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Purity: 98.05%

Catalog No. T15659Cas No. 1303470-48-5

KHK-IN-1 hydrochloride is a selective, cell-permeable, and efficient hexokinase (KHK) inhibitor, useful for studying diabetes and obesity.

Pack Size	Price	Availability
25 mg	$1,370	1-2 weeks
50 mg	$1,790	1-2 weeks
100 mg	$2,710	1-2 weeks

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Purity:98.05%

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COA

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	KHK-IN-1 hydrochloride is a selective, cell-permeable, and efficient hexokinase (KHK) inhibitor, useful for studying diabetes and obesity.
Targets&IC50	KHK:12nM
In vitro	Methods: HepG2 cells were treated with KHK-IN-1 hydrochloride (0-10 µM) and the level of KHK product F1P in cell lysates was measured using LC-MS quantification of F1P Results: KHK-IN-1 hydrochloride inhibited the production of F1P in HepG2 cell lysates with an IC50 value of 400 nM.[1]
In vivo	Methods: Rats were treated with KHK-IN-1 hydrochloride (10 mg/kg, oral) for pharmacokinetic studies. Results: KHK-IN-1 hydrochloride showed reasonable oral bioavailability in rats (F = 34%; oral t1/2 = 4 h); high distribution volume (Vdss = 32 L/kg) and high clearance (CL = 160 mL/min/kg); its plasma Cmax was only 0.16 μM.[2]

Chemical Properties

Molecular Weight	459.01
Formula	C₂₁H₂₇ClN₈S
Cas No.	1303470-48-5
Smiles	Cl.N=1C=NC=2C(=NC(=NC2C1NCC3CC3)N4CCNCC4)NC=5C=CC=CC5SC
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | store at -20°C | Shipping with blue ice.

Solubility Information

DMSO: 20 mg/mL (43.57 mM), Sonication is recommended.

H2O: 10 mg/mL (21.79 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1786 mL	10.8930 mL	21.7860 mL	108.9301 mL
5 mM	0.4357 mL	2.1786 mL	4.3572 mL	21.7860 mL
10 mM	0.2179 mL	1.0893 mL	2.1786 mL	10.8930 mL
20 mM	0.1089 mL	0.5447 mL	1.0893 mL	5.4465 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

KHK-IN-1 HydrochlorideKHKIN1 hydrochlorideKHK IN 1 hydrochloride