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KML-010

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Catalog No. T202891Cas No. 217635-62-6
Alias KML010, KML 010

KML-010 is a derivative of spiperone. Compared to spiperone, KML-010 exhibits slightly reduced affinity for 5-HT(2A) receptors, almost no affinity for 5-HT(2C) and 5-HT(1A) receptors, and significantly decreased affinity for dopamine D2 receptors. The modification of the N(1)-phenyl ring in spiperone to a methyl group in KML-010 alters its binding characteristics, potentially offering more selective pharmacological properties for specific receptor targeting.

KML-010

KML-010

😃Good
Catalog No. T202891Alias KML010, KML 010Cas No. 217635-62-6
KML-010 is a derivative of spiperone. Compared to spiperone, KML-010 exhibits slightly reduced affinity for 5-HT(2A) receptors, almost no affinity for 5-HT(2C) and 5-HT(1A) receptors, and significantly decreased affinity for dopamine D2 receptors. The modification of the N(1)-phenyl ring in spiperone to a methyl group in KML-010 alters its binding characteristics, potentially offering more selective pharmacological properties for specific receptor targeting.
Pack SizePriceAvailabilityQuantity
10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
KML-010 is a derivative of spiperone. Compared to spiperone, KML-010 exhibits slightly reduced affinity for 5-HT(2A) receptors, almost no affinity for 5-HT(2C) and 5-HT(1A) receptors, and significantly decreased affinity for dopamine D2 receptors. The modification of the N(1)-phenyl ring in spiperone to a methyl group in KML-010 alters its binding characteristics, potentially offering more selective pharmacological properties for specific receptor targeting.
AliasKML010, KML 010
Chemical Properties
Molecular Weight333.4
FormulaC18H24FN3O2
Cas No.217635-62-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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