Shopping Cart
- Remove All
Your shopping cart is currently empty
KT-333 ammonium
😃Good
Catalog No. T86788Cas No. 2839758-34-6
KT-333 ammonium (Compound A) acts as a molecular glue that targets and promotes the degradation of the STAT3 protein through the ubiquitin-proteasome system. This compound achieves selective degradation by binding simultaneously to the STAT3 protein and the E3 ubiquitin ligase von Hippel-Lindau protein (VHL). It exhibits strong selectivity and efficacy in degrading STAT3, possessing notable antitumor properties. KT-333 ammonium is particularly useful for research on hematologic malignancies, including large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL) [1].
KT-333 ammonium
😃Good
Catalog No. T86788Cas No. 2839758-34-6
KT-333 ammonium (Compound A) acts as a molecular glue that targets and promotes the degradation of the STAT3 protein through the ubiquitin-proteasome system. This compound achieves selective degradation by binding simultaneously to the STAT3 protein and the E3 ubiquitin ligase von Hippel-Lindau protein (VHL). It exhibits strong selectivity and efficacy in degrading STAT3, possessing notable antitumor properties. KT-333 ammonium is particularly useful for research on hematologic malignancies, including large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL) [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry |
Bulk & Custom
Add to Cart
Questions
View MoreContact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | KT-333 ammonium (Compound A) acts as a molecular glue that targets and promotes the degradation of the STAT3 protein through the ubiquitin-proteasome system. This compound achieves selective degradation by binding simultaneously to the STAT3 protein and the E3 ubiquitin ligase von Hippel-Lindau protein (VHL). It exhibits strong selectivity and efficacy in degrading STAT3, possessing notable antitumor properties. KT-333 ammonium is particularly useful for research on hematologic malignancies, including large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL) [1]. |
| In vitro | KT-333 ammonium, at a concentration of (11.8±2.3 nM over 48 hours), causes irreversible growth inhibition and induces the activity of caspase 3/7, a marker of apoptosis, in the SU-DHL-1 cell line following STAT3 degradation [1]. Additionally, KT-333 ammonium demonstrates STAT3 protein degradation with GI50 values ranging from 8.1 to 57.4 nM across various ALCL cell lines in cell phenotype analysis [1]. |
| In vivo | KT-333 ammonium exhibited dose-dependent antitumor activity when administered intravenously at doses of 5, 10, 15, and 45 mg/kg once weekly for two weeks. Mice receiving 5 mg/kg showed 79.9% tumor growth inhibition (TGI), while doses of 10, 15, or 45 mg/kg led to complete tumor regression, sustained until the study's conclusion [1]. Similarly, doses of 10, 20, and 30 mg/kg resulted in dose-dependent antitumor effects, with mice given 10 mg/kg achieving 83.8% TGI, and those receiving 20 or 30 mg/kg experiencing complete tumor regression, also persisting through to the end of the study [1]. |
| Molecular Weight | 1274.81 |
| Formula | C60H77ClN11O14PS |
| Cas No. | 2839758-34-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy KT-333 ammonium | purchase KT-333 ammonium | KT-333 ammonium cost | order KT-333 ammonium | KT-333 ammonium chemical structure | KT-333 ammonium in vivo | KT-333 ammonium in vitro | KT-333 ammonium formula | KT-333 ammonium molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.