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Lck-IN-2
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Catalog No. T86804Cas No. 2615173-24-3
Lck-IN-2 (compound 12a), an inhibitor of Lymphocyte-specific protein tyrosine kinase (Lck), demonstrates an IC50 of 10.6 nM. It displays efficacy in colon cancer cells, exhibiting GI50 values ranging from 0.24-1.26 μM. Furthermore, Lck-IN-2 induces apoptotic effects in Colo201 cells [1].
Lck-IN-2
😃Good
Catalog No. T86804Cas No. 2615173-24-3
Lck-IN-2 (compound 12a), an inhibitor of Lymphocyte-specific protein tyrosine kinase (Lck), demonstrates an IC50 of 10.6 nM. It displays efficacy in colon cancer cells, exhibiting GI50 values ranging from 0.24-1.26 μM. Furthermore, Lck-IN-2 induces apoptotic effects in Colo201 cells [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Lck-IN-2 (compound 12a), an inhibitor of Lymphocyte-specific protein tyrosine kinase (Lck), demonstrates an IC50 of 10.6 nM. It displays efficacy in colon cancer cells, exhibiting GI50 values ranging from 0.24-1.26 μM. Furthermore, Lck-IN-2 induces apoptotic effects in Colo201 cells [1]. |
| Targets&IC50 | Lck:10.6 nM |
| Molecular Weight | 596.64 |
| Formula | C31H32N8O5 |
| Cas No. | 2615173-24-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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