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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 10-14 weeks | |
50 mg | $1,980 | 10-14 weeks | |
100 mg | $2,500 | 10-14 weeks |
Description | LolCDE-IN-2 is a potent inhibitor of the Lol protein (LolCDE) and demonstrates antibacterial activity against E. coli MG1655, with a minimum inhibitory concentration (MIC) of 2 μg/ml [1]. |
In vitro | The P. aeruginosa ΔlolCDE::CTX-lolCDE E. coli strain becomes more susceptible to LolCDE-IN-2 (compound 2A) when either the MexAB-OprM efflux pump is lacking or the permeability of its OM is increased by the expression of the FpvA-ΔP protein; in each case, these strains show an MIC of 16 μg/ml [1]. LolCDE-IN-2 likely interacts with residues in the binding regions of E. coli LolCDE. |
Molecular Weight | 367.4 |
Formula | C22H17N5O |
Cas No. | 2748443-01-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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