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LSD1/HDAC6-IN-2

Name: LSD1/HDAC6-IN-2
Brand: TargetMol
SKU: T89134
Price: 30 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T89134Cas No. 2982787-50-6

LSD1/HDAC6-IN-2 (JBI-802) is an orally effective inhibitor targeting LSD1, HDAC6, and MAO-A, demonstrating IC50 values of 5 nM, 11 nM, and 5 nM, respectively. This compound effectively suppresses the growth of multiple myeloma cells, including MM.1S, MM.1R, and RPMI-8226. Additionally, LSD1/HDAC6-IN-2 is utilized for researching acute myeloid leukemia and lymphoma.

LSD1/HDAC6-IN-2

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Catalog No. T89134Cas No. 2982787-50-6

Pack Size	Price	Availability	Quantity
10 mg	Inquiry	10-14 weeks
50 mg	Inquiry	10-14 weeks

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Product Introduction

Bioactivity

Description	LSD1/HDAC6-IN-2 (JBI-802) is an orally effective inhibitor targeting LSD1, HDAC6, and MAO-A, demonstrating IC50 values of 5 nM, 11 nM, and 5 nM, respectively. This compound effectively suppresses the growth of multiple myeloma cells, including MM.1S, MM.1R, and RPMI-8226. Additionally, LSD1/HDAC6-IN-2 is utilized for researching acute myeloid leukemia and lymphoma.
Targets&IC50	MAO-B:6600 nM, HDAC6:11 nM, MAO-A:5 nM
In vitro	LSD1/HDAC6-IN-2 (JBI-802) exhibits growth inhibitory activity against multiple myeloma cells MM.1S, MM.1R, and RPMI-8226, with EC50 values of 2 nM, 6 nM, and 280 nM, respectively.
In vivo	LSD1/HDAC6-IN-2 (JBI-802), administered orally at a dosage of 25 mg/kg once daily for 12 days, exhibits antitumor activity in a mouse model of multiple myeloma.

Chemical Properties

Molecular Weight	443.34
Formula	C₂₁H₂₃BrN₄O₂
Cas No.	2982787-50-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc