LTD4 antagonist 1

LTD4 antagonist 1 is a potent and orally active antagonist of leukotriene D4 (LTD4; Ki: 0.57 nM).

Catalog No. T10057Cas No. 136564-67-5

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LTD4 antagonist 1

Catalog No. T10057Cas No. 136564-67-5

LTD4 antagonist 1 is a potent and orally active antagonist of leukotriene D4 (LTD4; Ki: 0.57 nM).

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Pack Size	Price	Availability
25 mg	$2,420	10-14 weeks
50 mg	$3,180	10-14 weeks
100 mg	$4,300	10-14 weeks

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Product Introduction

Bioactivity

Description	LTD4 antagonist 1 is a potent and orally active antagonist of leukotriene D4 (LTD4; Ki: 0.57 nM).
Targets&IC50	LTD4:0.57 nM (ki)
In vitro	LTD4 antagonist 1 (Compound 38b) shows a Ki of 0.57 nM for the displacement of [3H]LTD4 on guinea pig lung membranes, a pKB of 9.93 versus LTE4 on guinea pig trachea.
In vivo	LTD4 antagonist 1 shows a ED50 (i.v.)/ED50 (p.o.) of 0.036 and 1.44 μmol/kg in LTD4-induced bronchoconstriction in guinea pigs.

Chemical Properties

Molecular Weight	615.66
Formula	C₃₁H₃₂F₃N₃O₅S
Cas No.	136564-67-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

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