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m-PEG3-NHS ester

Name: m-PEG3-NHS ester
Brand: TargetMol
SKU: T15859
Price: 87 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T15859Cas No. 876746-59-7

m-PEG3-NHS ester is a PEG-based linker essential for PROTACs, facilitating the conjugation of two vital ligands necessary for PROTAC formation, thereby enabling selective protein degradation via the ubiquitin-proteasome system within cells.

m-PEG3-NHS ester

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Catalog No. T15859Cas No. 876746-59-7

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Product Introduction

Bioactivity

Description	m-PEG3-NHS ester is a PEG-based linker essential for PROTACs, facilitating the conjugation of two vital ligands necessary for PROTAC formation, thereby enabling selective protein degradation via the ubiquitin-proteasome system within cells.
In vitro	PROTACs consist of two different ligands linked together: one binds to an E3 ubiquitin ligase, and the other to the target protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Chemical Properties

Molecular Weight	289.28
Formula	C₁₂H₁₉NO₇
Cas No.	876746-59-7
Relative Density.	1.25 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

m-PEG-3-NHS esterm-PEG3-NHS estermPEG3NHS esterm PEG3 NHS ester